Am J Stem Cell 2011;1(1):42-47

Review Article
Regulators of human adipose-derived stem cell self-renewal

Phi Villageois, Brigitte Wdziekonski, Laure-Emmanuelle Zaragosi, Magali Plaisant, Tala Mohsen-Kanson, Nadège Lay, Annie Ladoux,
Pascal Peraldi, Christian Dani

Université de Nice Sophia-Antipolis, Institut Biologie du Développement et Cancer, CNRS UMR 6543, Faculté de Médecine, 28 avenue
de Valombrose, 06108 Nice Cedex 2, France.

Received July 26, 2011; accepted August 11, 2011; Epub August 18, 2011; published January 1, 2012

Abstract: Adipose tissue is an alternative source of mesenchymal stem cells and human adipose-derived stem cells (ASCs) display an
attractive and substantial therapeutic potential when transplanted in animal models. To this end, an understanding of ASC biology is
necessary and the knowledge of mechanisms that maintain ASCs in an undifferentiated state with no loss of differentiation potential
during ex vivo expansion represents a crucial step. However, these mechanisms remain to be identified because appropriate human
cellular models are scant. In this review we will describe a cellular model isolated from human adipose tissue displaying all the features
of stem cells. Then, we will focus on the identification of intrinsic and extrinsic factors regulating the balance between human ASC
proliferation and differentiation. We will point out the role of factors secreted by undifferentiated ASCs, such a FGF2, activin A, BMP4,
Hedgehog molecules and secreted by adipose tissue macrophages. Finally, we will outline the role of miRNAs in these processes.

Keywords: Adipose-derived stem cells, proliferation, adipocyte differentiation, FGF2, activin A, miR30, Hedgehog

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Address all correspondence to:
Christian Dani, PhD
Université de Nice Sophia-Antipolis
Institut Biologie du Développement et Cancer
CNRS UMR 6543, Faculté de Médecine
28 avenue de Valombrose
06108 Nice Cedex 2, France.
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