Am J Stem Cell 2012;1(1):48-58
Intrinsic regulation of adult subventricular zone neural progenitor cells and the effect
of brain injury
Kathryn S Jones, Bronwen Connor
Department of Pharmacology and Clinical Pharmacology, Centre for Brain Research, Faculty of Medical and Health Sciences, University
of Auckland, Private Bag 92019, Auckland, New Zealand.
Received August 1, 2011; accepted August 9, 2011; Epub August 18, 2011; published January 1, 2012
Abstract: Regulation over the generation of adult born neuroblasts and oligodendrocyte precursor cells is governed by a myriad of
extracellular signals. These signals must be related into the cell nucleus to regulate cell cycle and cell lineage maturation programmes.
This internal regulation is controlled by proneural and anti-neurogenic transcription factors, including Mash1, Pax6, Dlx2 and Olig2. This
review will cover how transcription factors regulate adult SVZ neurogenesis; the progression from neural stem cell, to transit amplifying
precursor cell, to neuroblast or oligodendrocyte precursor cell, and how transcription factors influence neuronal subtype specification.
Changes to transcriptional regulation that occur after brain injury and what this means for endogenous brain repair strategies will also
be covered. (AJSC1108001).
Keywords: Adult neurogenesis, subventricular zone, intrinsic regulation, brain injury, proneural transcription factor, Mash1, Pax6, Dlx2,
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Address all correspondence to:
Dr. Bronwen Connor
Department of Pharmacology and Clinical Pharmacology
Centre for Brain Research, Faculty of Medical and Health Sciences
University of Auckland, Private Bag 92019
Auckland, New Zealand.
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