Am J Stem Cells 2013;2(2):132-136

Case Report
Pancytopenia related to dental adhesive in a young patient

Farhad Khimani, William Tse, Ryan Livengood, Ludwig Gutmann, Jeffrey A Vos, Vivek Abhyankar

Hematology/Oncology Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, USA; Department of Pathology,
West Virginia University, Morgantown, WV, USA; Department of Neurology, West Virginia University, Morgantown, WV, USA; Community
Oncologist, Marietta, OH, USA

Received March 7, 2013; Accepted May 27, 2013; Epub June 30, 2013; Published July 15, 2013

Abstract: Copper deficiency resulting in hypocupremia is a rare cause of pancytopenia associated with a neurological syndrome.
Hypocupremia may also occur as a consequence of excessive oral zinc consumption as described by Brewer et al and several other
groups. Dental fixatives have been described as a potential source of hyperzincemia in patients. Despite the reported case reports and
cohorts the data on this subject is sparse and patients are still being misdiagnosed. Moreover, the use of zinc containing dental fixatives
continues and remains an unresolved issue. We describe a case of a patient with pancytopenia who was diagnosed with severe
aplastic anemia and hypocellular myelodysplastic syndrome and was referred to us for consideration of bone marrow transplantation.
(AJSC1303002).

Keywords: Pancytopenia, dental, adhesive

Address correspondence to: Dr. Joel S George, Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9300, 1848
Health Sciences South, Morgantown, WV, USA. Phone: 304-293-4499; Fax: 304-293-4667; E-mail: jsgeorge@hsc.wvu.edu
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